|
1-Acylglycerol-3-Phosphocholine Acyltransferase, Lysophospholipid acyltransferase
|
|
|
acyl-CoA |
|
CoA |
|
1-acyl-sn-glycero-3-phosphocholine |
|
1,2-diacyl-sn-glycero-3-phosphocholine |
|
|
|
Locus Data & Links (May need to scroll right or left to show columns)
|
|
|
LPLAT1 / LPCAT1
|
|
|
Endomembrane
|
Mutant Char.; Heterol Exp'n.; Seq. Similarity; in vitro assay
|
5 Refs
Bates, P.D., Fatihi, A., Snapp, A.R., Carlsson, A.S., Browse, J., and Lu, C.F. (2012). Acyl Editing and Headgroup Exchange Are the Major Mechanisms That Direct Polyunsaturated Fatty Acid Flux into Triacylglycerols. Plant Physiology 160 ,1530-1539.Stahl, U., Stalberg, K., Stymne, S., and Ronne, H. (2008). A family of eukaryotic lysophospholipid acyltransferases with broad specificity. FEBS Lett. 582 , 305-309.Zhao, Y., Chen, Y.Q., Bonacci, T.M., Bredt, D.S., Li, S.Y., Bensch, W.R., Moller, D.E., Kowala, M., Konrad, R.J., and Cao, G.Q. (2008). Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. Journal of Biological Chemistry 283 , 8258-8265.Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008). Discovery essential of a lysophospholipid acyltransferase family for membrane asymmetry and diversity. Proceedings of the National Academy of Sciences of the United States of America 105 , 2830-2835.Xu, J., Carlsson, A.S., Francis, T., Zhang, M., Hoffman, T., Giblin, M.E., and Taylor, D.C. (2012 ). Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2. BMC Plant Biol. 12, 4.
|
Seq. Similarity to mammalian LPCATs, preference for PC but acts on other lysophospholipids in vitro; single mutant has no seed phenotype, but double mutant lpcat1/lpcat2 show increased contents of VLCFAs and decreased PUFA in TAG
|
|
|
Data
|
|
|
LPLAT2 / LPCAT2
|
|
|
Endomembrane
|
Mutant Char.; Heterol Exp'n.; Seq. Similarity; in vitro assay
|
5 Refs
Bates, P.D., Fatihi, A., Snapp, A.R., Carlsson, A.S., Browse, J., and Lu, C.F. (2012). Acyl Editing and Headgroup Exchange Are the Major Mechanisms That Direct Polyunsaturated Fatty Acid Flux into Triacylglycerols. Plant Physiology 160 ,1530-1539.Stahl, U., Stalberg, K., Stymne, S., and Ronne, H. (2008). A family of eukaryotic lysophospholipid acyltransferases with broad specificity. FEBS Lett. 582 , 305-309.Zhao, Y., Chen, Y.Q., Bonacci, T.M., Bredt, D.S., Li, S.Y., Bensch, W.R., Moller, D.E., Kowala, M., Konrad, R.J., and Cao, G.Q. (2008). Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. Journal of Biological Chemistry 283 , 8258-8265.Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008). Discovery essential of a lysophospholipid acyltransferase family for membrane asymmetry and diversity. Proceedings of the National Academy of Sciences of the United States of America 105 , 2830-2835.Xu, J., Carlsson, A.S., Francis, T., Zhang, M., Hoffman, T., Giblin, M.E., and Taylor, D.C. (2012 ). Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2. BMC Plant Biol. 12, 4.
|
Seq. Similarity to mammalian LPCATs, preference for PC but acts on other lysophospholipids in vitro; single mutant has no seed phenotype, but double mutant lpcat1/lpcat2 show increased contents of VLCFAs and decreased PUFA in TAG
|
|
|
Data
|
|
|
LPLAT
|
|
|
|
Heterol Exp'n; enzyme assay
|
1 Ref
|
Demonstrated activity with 1-acyl-lyso-PE and 1-acyl-lyso-PG in vitro
|
|
|
|
|
|
LPEAT1
|
|
|
|
Heterol Exp'n.; Seq. Similarity
Heterol Exp'n; enzyme assay
|
1 Ref
|
Preference for 1-acyl-lyso-PE, but will acylate other lysophospholipids in vitro
|
|
|
Data
|
|
|
LPEAT2
|
|
|
|
Heterol Exp'n.; Seq. Similarity
Heterol Exp'n; enzyme assay
|
1 Ref
|
Preference for 1-acyl-lyso-PE, but will acylate other lysophospholipids in vitro
|
|
|
Data
|
|
|
|
|
|
|
|
|
|
|
|
|
|
