Acyl Lipids: locations

ARABIDOPSIS
ACYL-LIPID METABOLISM

ENZYME & PROTEIN DATA

Acyl-CoA Oxidase

O₂

H₂O₂

acyl-Coenzyme A

Reaction

trans-2,3-dehydroacyl-Coenzyme A

Brenda: [1.3.3.6]
IUBMB: [1.3.3.6]
ExPASy: [1.3.3.6]
ExplorEnz: [1.3.3.6]
PDB: [1.3.3.6]

Enzyme Pathways

TAG Degradation

Locus Data & Links (May need to scroll right or left to show columns)

Locus Id (TAIR Link)	Abbrev.	Mutant(s) (click for pop-up)	Pathway(s)	Subcelluar location	Evidence for function	Key References	Comments	Microarray Expression	Proteomics data	ESTexpression in other oilseeds
At1g06290	ACX3	acx3, ibr4	TAG Degradation	Peroxisome	Mutant Char.; Heterol Exp'n.	4 Refs Eastmond, P.J., Hooks, M., and Graham, I.A. (2000). The Arabidopsis acyl-CoA oxidase gene family. Biochemical Society Transactions 28 , 755-757. Rylott, E.L., Rogers, C.A., Gilday, A.D., Edgell, T., Larson, T.R., and Graham, I.A. (2003). Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. Journal of Biological Chemistry 278 , 21370-21377. Adham, A.R., Zolman, B.K., Millius, A., and Bartel, B. (2005). Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Plant J. 41 , 859-874. Khan, B.R., Adham, A.R., and Zolman, B.K. (2012). Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions. Plant Molecular Biology 78 , 45-58.	http://www.ncbi.nlm.nih.gov/pubmed/10918060?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=16			Data
At1g06310	ACX6	acx6	TAG Degradation	Peroxisome	Mutant Char.; Seq. Similarity	1 Ref Khan, B.R., Adham, A.R., and Zolman, B.K. (2012). Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions. Plant Molecular Biology 78 , 45-58.	High sequence similarity with ACX3 but lack of mutant phenotype suggests it does not make a significant contribution to straight chain fatty acid beta-oxidation or convershion of IBA to IAA. Adham AR, Zolman BK, Millius A, Bartel B. 2005. Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Plant J. 41:859-74			Data
At2g35690	ACX5	acx5	TAG Degradation	Peroxisome	Mutant Char.	1 Ref Adham, A.R., Zolman, B.K., Millius, A., and Bartel, B. (2005). Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Plant J. 41 , 859-874.	High sequence similarity with ACX1. Acx5 single mutant does not exhibit a phenotype but the acx1 acx5 double mutant shows an altered response to IBA compared to single mutants. Adham AR, Zolman BK, Millius A, Bartel B. 2005. Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Plant J. 41:859-74			Data
At3g51840	ACX4	acx4	TAG Degradation	Peroxisome	Mutant Char.; Heterol Exp'n.	4 Refs Hayashi, H., De Bellis, L., Ciurli, A., Kondo, M., Hayashi, M., and Nishimura, R. (1999). A novel acyl-CoA oxidase that can oxidize short-chain acyl-CoA in plant peroxisomes. J. Biol. Chem. 274 , 12715-12721. Rylott, E.L., Rogers, C.A., Gilday, A.D., Edgell, T., Larson, T.R., and Graham, I.A. (2003). Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. Journal of Biological Chemistry 278 , 21370-21377. Graham, I.A. (2008). Seed storage oil mobilization. Ann. Rev. Plant Biol. 59 , 115-142. Review Khan, B.R., Adham, A.R., and Zolman, B.K. (2012). Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions. Plant Molecular Biology 78 , 45-58.	http://www.ncbi.nlm.nih.gov/pubmed/12481085?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1			Data
At4g16760	ACX1	acx1	TAG Degradation	Peroxisome	Mutant Char.; Heterol Exp'n.	3 Refs Pinfield-Wells, H., Rylott, E.L., Gilday, A.D., Graham, S., Job, K., Larson, T.R., and Graham, I.A. (2005). Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism. Plant J. 43 , 861-872. Graham, I.A. (2008). Seed storage oil mobilization. Ann. Rev. Plant Biol. 59 , 115-142. Review Hooks, M.A., Fleming, Y., Larson, T.R., and Graham, I.A. (1999). No Induction of beta-oxidation in leaves of Arabidopsis that over-produce lauric acid. Planta 207 , 385-392.	Sucrose-independent germination phenotype			Data
At5g65110	ACX2	acx2	TAG Degradation	Peroxisome	Mutant Char.	3 Refs Hooks, M.A., Kellas, F., and Graham, I.A. (1999). Long-chain acyl-CoA oxidases of Arabidopsis. Plant J. 20 , 1-13. Pinfield-Wells, H., Rylott, E.L., Gilday, A.D., Graham, S., Job, K., Larson, T.R., and Graham, I.A. (2005). Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism. Plant J. 43 , 861-872. Graham, I.A. (2008). Seed storage oil mobilization. Ann. Rev. Plant Biol. 59 , 115-142. Review	Carbon provision for the beta-oxidation pathway during germination or in dormant seeds.			Data