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Acetyl-CoA Carboxylase (Homomeric)
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Acetyl-CoA Carboxylase (Homomeric)
Overall Reaction
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ATP +HCO3- |
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ADP+ Pi |
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acetyl-Coenzyme A |
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malonyl-Coenzyme A |
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Activity: covalent binding of CO2 to biotin prosthetic group. |
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A Domain Of The
Acetyl-CoA Carboxylase (Homomeric)
With
Biotin Carboxylase
Activity
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ATP+HCO3- |
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ADP+ phosphate |
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biotin-carboxyl-carrier protein |
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carboxybiotin-carboxyl-carrier protein |
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A Domain Of The
Acetyl-CoA Carboxylase (Homomeric)
With
Carboxyltransferase
Activity
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a carboxylated-biotinylated-BCCP |
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a biotinylated-BCCP |
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acetyl-CoA |
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malonyl-CoA |
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Locus Data & Links (May need to scroll right or left to show columns)
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ACC1
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Cytosol Homomeric
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Mutant Char.
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3 Refs
Baud, S., Guyon, V., Kronenberger, J., Wuilleme, S., Miquel, M., Caboche, M., Lepiniec, L., and Rochat, C. (2003). Multifunctional acetyl-CoA carboxylase 1 is essential for very long chain fatty acid elongation and embryo development in Arabidopsis. Plant J. 33 , 75-86.Yanai, Y., Kawasaki, T., Shimada, H., Wurtele, E.S., Nikolau, B.J., and Ichikawa, N. (1995). GENOMIC ORGANIZATION OF 251 KDA ACETYL-COA CARBOXYLASE GENES IN ARABIDOPSIS - TANDEM GENE DUPLICATION HAS MADE 2 DIFFERENTIALLY EXPRESSED ISOZYMES. Plant and Cell Physiology 36 , 779-787.Lu, S.Y., Zhao, H.Y., Parsons, E.P., Xu, C.C., Kosma, D.K., Xu, X.J., Chao, D., Lohrey, G., Bangarusamy, D.K., Wang, G., Bressan, R.A., and Jenks, M.A. (2011). The glossyhead1 Allele of ACC1 Reveals a Principal Role for Multidomain Acetyl-Coenzyme A Carboxylase in the Biosynthesis of Cuticular Waxes by Arabidopsis. Plant Physiology 157 , 1079-1092.
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An allele of ACC1, gsd1 has glossy stems, 40% reduction of cuticular waxes, and shows postgenital organ fusion.
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Data
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ACC2
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Plastid Homomeric
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Seq. Similarity
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1 Ref
Moreau, K., Dizin, E., Ray, H., Luquain, C., Lefai, E., Foufelle, F., Billaud, M., Lenoir, G.M., and Dalla Venezia, N. (2006). BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. Journal of Biological Chemistry 281 , 3172-3181.
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Seq. Similarity to human ACCase
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Data
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