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NADPH + H+ |
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NADP+ |
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very long-chain 3-ketoacyl-Coenzyme A (=C20) |
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very long-chain (S)-3-hydroxyacyl-Coenzyme A |
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Locus Data & Links (May need to scroll right or left to show columns)
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KCR2
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Mutant Char.; Seq. Similarity; Upregulated in epidermis
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3 Refs
Beaudoin, F., Wu, X.Z., Li, F.L., Haslam, R.P., Markham, J.E., Zheng, H.Q., Napier, J.A., and Kunst, L. (2009). Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiol. 150 , 1174-1191.Beaudoin, F., Gable, K., Sayanova, O., Dunn, T., and Napier, J.A. (2002). A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry 277 , 11481-11488.Xu, X.J., Dietrich, C.R., Delledonne, M., Xia, Y.J., Wen, T.J., Robertson, D.S., Nikolau, B.J., and Schnable, P.S. (1997). Sequence analysis of the cloned glossy8 gene of maize suggests that it may code for a beta-ketoacyl reductase required for the biosynthesis of cuticular waxes. Plant Physiology 115 , 501-510.
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no mutant phenotype detected; no KCR activity in yeast
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Data
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KCR1
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Endomembrane
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Mutant Char.; RNAi; Comple. of yeast mutant
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3 Refs
Beaudoin, F., Gable, K., Sayanova, O., Dunn, T., and Napier, J.A. (2002). A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry 277 , 11481-11488.Beaudoin, F., Wu, X.Z., Li, F.L., Haslam, R.P., Markham, J.E., Zheng, H.Q., Napier, J.A., and Kunst, L. (2009). Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiol. 150 , 1174-1191.Xu, X.J., Dietrich, C.R., Delledonne, M., Xia, Y.J., Wen, T.J., Robertson, D.S., Nikolau, B.J., and Schnable, P.S. (1997). Sequence analysis of the cloned glossy8 gene of maize suggests that it may code for a beta-ketoacyl reductase required for the biosynthesis of cuticular waxes. Plant Physiology 115 , 501-510.
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knock-out is embyro lethal; suppressed lines have pleiotropic effects on plant development due to general effect on fatty acid elongation
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Data
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