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Pyruvate Dehydrogenase Complex
(
Heteromeric
)
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Pyruvate Dehydrogenase alpha subunit, E1a component of Pyruvate Dehydrogenase Complex
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| [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine |
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CO2 |
| pyruvate |
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[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine |
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Pyruvate Dehydrogenase beta subunit, E1b component of Pyruvate Dehydrogenase Complex
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| [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine |
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CO2 |
| pyruvate |
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[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine |
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Dihydrolipoamide Acetyltransferase, E2 component of Pyruvate Dehydrogenase Complex
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| acetyl-CoA |
|
CoA |
| enzyme N6-(dihydrolipoyl)lysine |
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enzyme N6-(S-acetyldihydrolipoyl)lysine |
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Dihydrolipoamide Dehydrogenase, E3 component of Pyruvate Dehydrogenase Complex
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| NAD+ |
|
NADH + H+ |
| protein N6-(dihydrolipoyl)lysine |
|
protein N6-(lipoyl)lysine |
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Locus Data & Links (May need to scroll right or left to show columns)
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PDH (E1 alpha)
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Fatty Acid Synth
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Plastid
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Seq. Similarity
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2 Refs
Demeirleir, L., Lissens, W., Vamos, E., and Liebaers, I. (1992). Pyruvate-Dehydrogenase (Pdh) Deficiency Caused by a 21-Base Pair Insertion Mutation in the E1-Alpha Subunit. Human Genetics 88 , 649-652.Johnston, M.L., Luethy, M.H., Miernyk, J.A., and Randall, D.D. (1997). Cloning and molecular analyses of the Arabidopsis thaliana plastid pyruvate dehydrogenase subunits. Biochim. Biophys. Acta, Bioenerg. 1321 , 200-206.
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Seq. Similarity to human PDH E1 a1 precursor
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Data
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PDH (E1 beta )
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Fatty Acid Synth
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Plastid
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Seq. Similarity
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2 Refs
Brown, R.M., Head, R.A., Boubriak, II, Leonard, J.V., Thomas, N.H., and Brown, G.K. (2004). Mutations in the gene for the E1 beta subunit: a novel cause of pyruvate dehydrogenase deficiency. Human Genetics 115 , 123-127.Johnston, M.L., Luethy, M.H., Miernyk, J.A., and Randall, D.D. (1997). Cloning and molecular analyses of the Arabidopsis thaliana plastid pyruvate dehydrogenase subunits. Biochim. Biophys. Acta, Bioenerg. 1321 , 200-206.
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Seq. Similarity to human PDH E1-1 precursor
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Data
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EMB3003 (E2 )
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Fatty Acid Synth
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Plastid
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Mutant Char.
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1 Ref
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Data
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PDH (E1 beta )
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Fatty Acid Synth
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Plastid
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Seq. Similarity
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2 Refs
Brown, R.M., Head, R.A., Boubriak, II, Leonard, J.V., Thomas, N.H., and Brown, G.K. (2004). Mutations in the gene for the E1 beta subunit: a novel cause of pyruvate dehydrogenase deficiency. Human Genetics 115 , 123-127.Johnston, M.L., Luethy, M.H., Miernyk, J.A., and Randall, D.D. (1997). Cloning and molecular analyses of the Arabidopsis thaliana plastid pyruvate dehydrogenase subunits. Biochim. Biophys. Acta, Bioenerg. 1321 , 200-206.
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Seq. Similarity to human PDH E1-1 precursor
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Data
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LPD1 (E3)
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Fatty Acid Synth
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Plastid
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Mutant Char.; Seq. Similarity
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2 Refs
Chen, W.H., Chi, Y.J., Taylor, N.L., Lambers, H., and Finnegan, P.M. (2010). Disruption of ptLPD1 or ptLPD2, Genes That Encode Isoforms of the Plastidial Lipoamide Dehydrogenase, Confers Arsenate Hypersensitivity in Arabidopsis. Plant Physiology 153 ,1385-1397.Engels, A., and Pistorius, E.K. (1997). Characterization of a gene encoding dihydrolipoamide dehydrogenase of the cyanobacterium Synechocystis sp. Strain PCC 6803. Microbiology-Uk 143 , 3543-3553.
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Seq. Similarity to Synechocystis PDH E3 component
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Data
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LTA2 (E2)
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Fatty Acid Synth
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Plastid
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Mutant Char.; Heterol Exp'n.
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2 Refs
Lin, M., Behal, R., and Oliver, D.J. (2003). Disruption of plE2, the gene for the E2 subunit of the plastid pyruvate dehydrogenase complex, in Arabidopsis causes an early embryo lethal phenotype. Plant Mol. Biol. 52 , 865-872.Mooney, B.P., Miernyk, J.A., and Randall, D.D. (1999). Cloning and characterization of the dihydrolipoamide S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) from arabidopsis. Plant Physiology 120 , 443-451.
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Data
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LPD2 (E3)
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Fatty Acid Synth
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Plastid
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Mutant Char.; Seq. Similarity
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2 Refs
Chen, W.H., Chi, Y.J., Taylor, N.L., Lambers, H., and Finnegan, P.M. (2010). Disruption of ptLPD1 or ptLPD2, Genes That Encode Isoforms of the Plastidial Lipoamide Dehydrogenase, Confers Arsenate Hypersensitivity in Arabidopsis. Plant Physiology 153 ,1385-1397.Engels, A., and Pistorius, E.K. (1997). Characterization of a gene encoding dihydrolipoamide dehydrogenase of the cyanobacterium Synechocystis sp. Strain PCC 6803. Microbiology-Uk 143 , 3543-3553.
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Seq. Similarity to Synechocystis PDH E3 component
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Data
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