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Hydroxyacyl-CoA Dehydratase
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very long-chain (S)-3-hydroxyacyl-Coenzyme A (=C20)
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very long-chaintrans-2-enoyl-Coenzyme A
+ H2O
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Locus Data & Links (May need to scroll right or left to show columns)
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HCD / PAS2
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Endomembrane
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Mutant Char.; Comple. of yeast mutant
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2 Refs
Bach, L., Michaelson, L.V., Haslam, R., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J.-P., Miquel, M., Tellier, F., Domergue, F., Markham, J.E., Beaudoin, F., Napier, J.A., and Faure, J.-D. (2008). The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences of the United States of America 105 , 14727-14731.Bellec, Y., Harrar, Y., Butaeye, C., Darnet, S., Bellini, C., and Faure, J.D. (2002). Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Plant Journal 32 ,713-722.
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Function shown in wax and sphingolipid biosynthesis. knockout is embryo lethal; pas2-1 has general reduction of VLCFA pools in seed storage triacylglycerols, cuticular waxes, and complex sphingolipids
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Data
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Seq. Similarity
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1 Ref
Bach, L., Michaelson, L.V., Haslam, R., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J.-P., Miquel, M., Tellier, F., Domergue, F., Markham, J.E., Beaudoin, F., Napier, J.A., and Faure, J.-D. (2008). The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences of the United States of America 105 , 14727-14731.
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Does not complement yeast phs1 mutant, possibly not an active HCD
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Data
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