Acyl Lipids: enzymes

ARABIDOPSIS
ACYL-LIPID METABOLISM

ENZYME & PROTEIN DATA

Lipoxygenase

(9cis)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate

Reaction_

(15cis)-12-oxophyto-10,15-dienoate

Brenda: [1.13.11.12] [5.3.99.6]
IUBMB: [1.13.11.12] [5.3.99.6]
ExPASy: [1.13.11.12] [5.3.99.6]
ExplorEnz: [1.13.11.12] [5.3.99.6]
PDB: [1.13.11.12] [5.3.99.6]

(9cis,11trans,14cis)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate

Reaction_

(9cis)-(13S)-12,13-epoxyoctadeca-9,11-dienoate
+ H₂O

Brenda: [1.13.11.12] [4.2.1.51]
IUBMB: [1.13.11.12] [4.2.1.51]
ExPASy: [1.13.11.12] [4.2.1.51]
ExplorEnz: [1.13.11.12] [4.2.1.51]
PDB: [1.13.11.12] [4.2.1.51]

O₂+
7cis,10cis, 13cis-hexadecatrienoateÂ (16:3)

Reaction_

11S-hydroperoxy-7cis, 9trans, 13cis-hexadecatrienoate

Brenda: [1.13.11.12]
IUBMB: [1.13.11.12]
ExPASy: [1.13.11.12]
ExplorEnz: [1.13.11.12]
PDB: [1.13.11.12]

O₂+
9cis, 12cis, 15cis-octadecadienoateÂ (linolenate, 18:3)

Reaction_

9S-hydroperoxy- 10trans, 12cis, 15cis-octadecatrienoate

Brenda: [1.13.11.12]
IUBMB: [1.13.11.12]
ExPASy: [1.13.11.12]
ExplorEnz: [1.13.11.12]
PDB: [1.13.11.12]

O₂+
9cis, 12cis, 15cis-octadecadienoate (linolenate, 18:3)

Reaction_

13S-hydroperoxy- 9cis, 11trans, 15cis-octadecatrienoate

Brenda: [1.13.11.12]
IUBMB: [1.13.11.12]
ExPASy: [1.13.11.12]
ExplorEnz: [1.13.11.12]
PDB: [1.13.11.12]

O₂+
9cis, 12cis-octadecadienoateÂ (linoleate, 18:2)

Reaction_

13S-hydroperoxy- 9cis, 11trans-octadecadienoate

Brenda: [1.13.11.12]
IUBMB: [1.13.11.12]
ExPASy: [1.13.11.12]
ExplorEnz: [1.13.11.12]
PDB: [1.13.11.12]

O₂+
9cis, 12cis-octadecadienoateÂ (linoleate, 18:2)

Reaction_

9S-hydroperoxy- 10trans, 12cis-octadecadienoate

Brenda: [1.13.11.12]
IUBMB: [1.13.11.12]
ExPASy: [1.13.11.12]
ExplorEnz: [1.13.11.12]
PDB: [1.13.11.12]

Enzyme Pathways

Oxylipin I | Oxylipin II

Locus Data & Links (May need to scroll right or left to show columns)

Locus Id (TAIR Link)	Abbrev.	Mutant(s) (click for pop-up)	Pathway(s)	Subcelluar location	Evidence for function	Key References	Comments	Microarray Expression	Proteomics data	ESTexpression in other oilseeds
At1g17420			Oxylipin I Oxylipin II
At1g55020	LOX5	lox1	Oxylipin I Oxylipin II	Cytosol	Mutant Char.	1 Ref Vellosillo, T., Martinez, M., Lopez, M.A., Vicente, J., Cascon, T., Dolan, L., Hamberg, M., and Castresana, C. (2007). Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. Plant Cell 19 ,831-846.	expressed in lateral root primordia, mutant has increased number of lateral roots
At1g67560	LOX6	lox6	Oxylipin I Oxylipin II		Mutant Char.	1 Ref Grebner, W., Stingl, N.E., Oenel, A., Mueller, M.J., and Berger, S. (2013). Lipoxygenase6-Dependent Oxylipin Synthesis in Roots Is Required for Abiotic and Biotic Stress Resistance of Arabidopsis. Plant Physiology 161 ,2159-2170.	Synthesis of jasmonates is induced upon wounding in roots.
At1g72520			Oxylipin I Oxylipin II
At3g22400	LOX5	lox5	Oxylipin I Oxylipin II	Cytosol	Mutant Char.	1 Ref Vellosillo, T., Martinez, M., Lopez, M.A., Vicente, J., Cascon, T., Dolan, L., Hamberg, M., and Castresana, C. (2007). Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. Plant Cell 19 ,831-846.	expressed in lateral root primordia, mutant has increased number of lateral roots
At3g45140	LOX2	lox2	Oxylipin I Oxylipin II		Mutant Char.	1 Ref Glauser, G., Dubugnon, L., Mousavi, S.A.R., Rudaz, S., Wolfender, J.L., and Farmer, E.E. (2009). Velocity Estimates for Signal Propagation Leading to Systemic Jasmonic Acid Accumulation in Wounded Arabidopsis. Journal of Biological Chemistry 284 ,34506-34513.	The major roles of LOX2 are to generate arabidopsides and the large levels of JA that accumulate proximal to the wound