|
Acyl-CoA : Diacylglycerol Acyltransferase
|
|
|
acyl-Coenzyme A |
|
Coenzyme A |
|
1,2-diacylglycerol |
|
triacylglycerol |
|
|
|
Locus Data & Links (May need to scroll right or left to show columns)
|
|
|
DGAT3
|
|
|
Endomembrane
|
Mutant Char.; Seq. Similarity
|
2 Refs
Hernandez, M.L., Whitehead, L., He, Z.S., Gazda, V., Gilday, A., Kozhevnikova, E., Vaistij, F.E., Larson, T.R., and Graham, I.A. (2012). A Cytosolic Acyltransferase Contributes to Triacylglycerol Synthesis in Sucrose-Rescued Arabidopsis Seed Oil Catabolism Mutants. Plant Physiology 160 ,215-225.Saha, S., Enugutti, B., Rajakumari, S., and Rajasekharan, R. (2006). Cytosolic triacylglycerol biosynthetic pathway in oilseeds: Molecular cloning and expression of peanut cytosolic diacylglycerol acyltransferase. Plant Physiol. 141 , 1533-1543.
|
Seq. Similarity to peanut AhDGAT
|
|
|
Data
|
|
|
DGAT1
|
|
|
Endomembrane
|
Mutant Char.; in-planta Overexp'n.; Comple. of yeast mutants
|
3 Refs
Zou, J.T., Wei, Y.D., Jako, C., Kumar, A., Selvaraj, G., and Taylor, D.C. (19 99). The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene. Plant J. 19, 645-653Routaboul, J.M., Benning, C., Bechtold, N., Caboche, M., and Lepiniec, L. (1999). The TAG1 locus of Arabidopsis encodes for a diacylglycerol acyltransferase. Plant Physiol. Biochem. 37 , 831-840.Zhang, M., Fan, J.L., Taylor, D.C., and Ohlrogge, J.B. (2009). DGAT1 and PDAT1 Acyltransferases Have Overlapping Functions in Arabidopsis Triacylglycerol Biosynthesis and Are Essential for Normal Pollen and Seed Development. Plant Cell 21 , 3885-3901.
|
|
|
|
Data
|
|
|
DGAT2
|
|
|
Endomembrane
|
Heterol Exp'n.; Seq. Similarity
|
3 Refs
Zhou, X.R., Shrestha, P., Yin, F., Petrie, J.R., and Singh, S.P. (2013). AtDGAT2 is a functional acyl-CoA:diacylglycerol acyltransferase and displays different acyl-CoA substrate preferences than AtDGAT1. Febs Letters 587 ,2371-2376.Lardizabal, K.D., Mai, J.T., Wagner, N.W., Wyrick, A., Voelker, T., and Hawkins, D.J. (2001). DGAT2 is a new diacylglycerol acyltransferase gene family?Purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity. J. Biol. Chem. 276 , 38862-38869.Cheng, D., Nelson, T.C., Chen, J., Walker, S.G., Wardwell-Swanson, J., Meegalla, R., Taub, R., Billheimer, J.T., Ramaker, M., and Feder, J.N. (2003). Identification of acyl coenzyme A : Monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. Journal of Biological Chemistry 278 , 13611-13614.
|
Not identified, DGAT2 has closest homology to mammalian MGATs. Very weak in vitro activity when expressed in insect cells; however, fails to complement yeast TAG defective mutants.Very weak in vitro activity when expressed in insect cells; however, fails to complement yeast TAG defective mutants. Seq. Similarity to human MGAT3
|
|
|
Data
|
|
